In this section
@article{Ribeiro:2026:10.1186/s40658-026-00850-y,
author = {Ribeiro, D and Hallett, W and Howes, O and McCutcheon, R and Nour, MM and Nutt, D and Erritzoe, D and Agnorelli, C and Husbands, S},
doi = {10.1186/s40658-026-00850-y},
journal = {EJNMMI Phys},
title = {Evaluation of the impact of low activity imaging in [11C]-(+)-PHNO and [11C]UCB-J PET-MR scans.},
url = {http://dx.doi.org/10.1186/s40658-026-00850-y},
volume = {13},
year = {2026}
}
TY - JOUR
AB - INTRODUCTION: Positron Emission Tomography (PET) imaging is a close ally of Precision Medicine, and it has been proven to be indispensable in the field of Psychiatry. This imaging modality may also present an important role in understanding Neurodevelopmental disorders and their link to Psychiatric conditions, with new highly selective binders being used currently in research. PET imaging requires the administration of radiopharmaceuticals, where the radioisotope is in incorporated into a highly selective binder. Dosimetry and injected activity optimisation play a crucial role in the field of PET imaging as they allow to determine the radiation dose absorbed by target and non-target tissues, and determine the lowest amount required to deliver images with diagnostic quality and obtain reliable quantitative data, without overexposing patients. The aim of this research is to investigate the feasibility of reducing the injected activity of the [11C]-(+)-PHNO and [11C]UCB-J radiopharmaceuticals, for patients with neurodevelopmental disorders who undergo brain imaging in the PET-Magnetic Resonance (MR) scanner, without compromising quantitative accuracy of outcome measures. RESULTS: No statistically significant differences were found when comparing the 1/2 to 1/6 datasets with the full injected activity [11C]-(+)-PHNO dataset. Furthermore, the findings obtained from investigating the impact of low injected activity administrations of [11C]UCB-J revealed that it is possible to reduce the administered activity by 1/2, when the clinical outcome measure under evaluation is the binding potential relative to non-displaceable volume (BPND). When the outcome measure under investigation is the standard uptake volume ratio (SUVR), it is possible to decrease the injected activity to 1/3, for [11C]UCB-J. CONCLUSIONS: The simulation and analysis methodologies deployed in this project are suitable for investigating scans with low injected activity for tracers with cortical and striatal
AU - Ribeiro,D
AU - Hallett,W
AU - Howes,O
AU - McCutcheon,R
AU - Nour,MM
AU - Nutt,D
AU - Erritzoe,D
AU - Agnorelli,C
AU - Husbands,S
DO - 10.1186/s40658-026-00850-y
PY - 2026///
SN - 2197-7364
TI - Evaluation of the impact of low activity imaging in [11C]-(+)-PHNO and [11C]UCB-J PET-MR scans.
T2 - EJNMMI Phys
UR - http://dx.doi.org/10.1186/s40658-026-00850-y
UR - https://www.ncbi.nlm.nih.gov/pubmed/41806046
VL - 13
ER -
