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@article{Armstrong-James:2026,
author = {Armstrong-James, D},
journal = {BMJ Open Respiratory Research},
title = {Describing the burden and characteristics of Aspergillus- related chronic lung disease at ³Ô¹ÏºÚÁÏ College Healthcare Trust: a 10-year retrospective study},
year = {2026}
}
TY - JOUR
AB - Background: The epidemiology of Aspergillus-related chronic lung disease remains poorly defined. We aimed to characterise the local burden at ³Ô¹ÏºÚÁÏ College Healthcare NHS Trust (ICHT), London, across a 10-year period (2014-2024). Methods: Electronic health records were reviewed to identify individuals tested for serological markers of Aspergillus species infection after which thoracic CT scans were reviewed for features of Aspergillus-related chronic lung disease. Patients were classified into diagnostic categories based on definitions provided in the recent British Thoracic Society (BTS) Clinical Statement. Results: In total, 334 individuals met criteria for serologic Allergic Bronchopulmonary Aspergillosis (sABPA), 145 for Allergic Bronchopulmonary Aspergillosis (ABPA), 74 for Chronic Pulmonary Aspergillosis (CPA), 38 for Simple Aspergilloma and 11 with CPA-ABPA overlap. Serological responses varied: ABPA patients had higher median Aspergillus fumigatus-specific IgE titres (7.52 kUA/L, vs 1.94 kUA/L, p<0.05) and a greater proportion were positive for Aspergillus antibody (IgG) or precipitins (62.5% vs 32.9%, p<0.05) compared with sABPA. CPA patients had lower median total IgE (94 vs 1494 IU/mL, p<0.05) and A. fumigatus-specific IgE (2.24 vs 7.52 kUA/L, p<0.05) than ABPA patients. The was a wide spectrum of radiological presentations across diagnostic categories.Conclusions: While case numbers are likely underestimated, our findings highlight a substantial and heterogenous local burden. This improved understanding of local epidemiology will inform our local service development.
AU - Armstrong-James,D
PY - 2026///
SN - 2052-4439
TI - Describing the burden and characteristics of Aspergillus- related chronic lung disease at ³Ô¹ÏºÚÁÏ College Healthcare Trust: a 10-year retrospective study
T2 - BMJ Open Respiratory Research
ER -
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