BibTex format
@article{de:2026:10.1038/s41562-026-02551-z,
author = {de, Hoyos L and Schlag, F and Jahagirdar, S and Corfield, EC and Allegrini, AG and Admiraal, D and de, Zeeuw EL and Nolte, IM and Llonga, N and Neumann, A and Lange, K and van, den Bedem S and Du, Rietz E and Motazedi, E and Eising, E and Ng, NYT and Palviainen, T and Wang, CA and Thiering, E and Scatolin, S and Choudhary, P and Vilor-Tejedor, N and Liao, Z and Alemany, S and Pedersen, C-ET and Fernandez-Jimenez, N and Campbell, ML and Girchenko, P and Barthome, E and Martin, LC and Seelemeyer, H and Kumar, A and Jeanne, A and Ahluwalia, TS and Black, MH and Buitelaar, JK and Fisher, SE and Heiskala, A and Hernández-Lorca, M and Jaddoe, VW and Järvelin, M-R and Koopowitz, S-M and Lake, MT and Lichtenstein, P and Llop, S and Luo, M and Malmberg, A and MarÃ, S and Oldehinkel, AJ and Pausova, Z and Pennell, CE and Plomin, R and Reichborn-Kjennerud, T and Reilly, S and Rodriguez, A and Rolland, T and Ronald, A and Räikkönen, K and Shin, J and Artigas, MS and Tate, AE and Tiemeier, H and Ve},
doi = {10.1038/s41562-026-02551-z},
journal = {Nat Hum Behav},
title = {Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach.},
url = {http://dx.doi.org/10.1038/s41562-026-02551-z},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression meta-analysis of social behaviour from infancy to early adulthood, studying ~500,000 repeated measures in European-ancestry cohorts (N = 73,321). We modelled heterogeneity in single-variant associations across social domains (low prosocial behaviour and peer/social difficulties), multiple informants (parents, teachers and self-reports) and ages (2-29 years), identifying 6 associated loci, including variation within CADM2 (P = 2.51 × 10-9). Single nucleotide polymorphism-based heritability ranged from 2% to 7%, and the genetic architecture comprised 4 factors reflecting differences in either social domains or informants. Polygenic scores (N = 16,305) accurately predicted contextual variation in independent cohorts, with some cross-ancestry transferability. Context-specific patterns of genetic correlations, particularly when estimating the developmental onset of associations, offer opportunities to disentangle shared trajectories linking social behaviour with later-life and mental health outcomes.
AU - de,Hoyos L
AU - Schlag,F
AU - Jahagirdar,S
AU - Corfield,EC
AU - Allegrini,AG
AU - Admiraal,D
AU - de,Zeeuw EL
AU - Nolte,IM
AU - Llonga,N
AU - Neumann,A
AU - Lange,K
AU - van,den Bedem S
AU - Du,Rietz E
AU - Motazedi,E
AU - Eising,E
AU - Ng,NYT
AU - Palviainen,T
AU - Wang,CA
AU - Thiering,E
AU - Scatolin,S
AU - Choudhary,P
AU - Vilor-Tejedor,N
AU - Liao,Z
AU - Alemany,S
AU - Pedersen,C-ET
AU - Fernandez-Jimenez,N
AU - Campbell,ML
AU - Girchenko,P
AU - Barthome,E
AU - Martin,LC
AU - Seelemeyer,H
AU - Kumar,A
AU - Jeanne,A
AU - Ahluwalia,TS
AU - Black,MH
AU - Buitelaar,JK
AU - Fisher,SE
AU - Heiskala,A
AU - Hernández-Lorca,M
AU - Jaddoe,VW
AU - Järvelin,M-R
AU - Koopowitz,S-M
AU - Lake,MT
AU - Lichtenstein,P
AU - Llop,S
AU - Luo,M
AU - Malmberg,A
AU - MarÃ,S
AU - Oldehinkel,AJ
AU - Pausova,Z
AU - Pennell,CE
AU - Plomin,R
AU - Reichborn-Kjennerud,T
AU - Reilly,S
AU - Rodriguez,A
AU - Rolland,T
AU - Ronald,A
AU - Räikkönen,K
AU - Shin,J
AU - Artigas,MS
AU - Tate,AE
AU - Tiemeier,H
AU - Verhoef,E
AU - Vuoksimaa,E
AU - Wake,M
AU - Warrier,V
AU - Ystrom,E
AU - Bölte,S
AU - Ecker,C
AU - Bourgeron,T
AU - Lahti,J
AU - Stein,DJ
AU - Bilbao,JR
AU - Bønnelykke,K
AU - Bustamante,M
AU - Paus,T
AU - Middeldorp,CM
AU - Sunyer,J
AU - Sebert,S
AU - Standl,M
AU - Whitehouse,AJO
AU - Kaprio,J
AU - Ramos-Quiroga,JA
AU - Ribases,M
AU - Casas,M
AU - Bosch,R
AU - Morgan,AT
AU - Vrijkotte,TGM
AU - Larsson,H
AU - Cecil,CAM
AU - Hartman,CA
AU - Boomsma,DI
AU - Rimfeld,K
AU - Havdahl,A
AU - St,Pourcain B
DO - 10.1038/s41562-026-02551-z
PY - 2026///
TI - Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach.
T2 - Nat Hum Behav
UR - http://dx.doi.org/10.1038/s41562-026-02551-z
UR - https://www.ncbi.nlm.nih.gov/pubmed/42768150
ER -