Notable Recent Publications

These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.

Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay

This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans.  For more, please see the associated .

See our latest ANP32 papers here: ,, .

Daniel H. Goldhill, Aartjan J. W. te Velthuis, Robert A. Fletcher, Pinky Langat, Maria Zambon, Angie Lackenby & Wendy S. Barclay

This paper showed how influenza could evolve resistance to favipiravir, an antiviral that may be used to treat influenza. The residue that mutated to give resistance was highly conserved suggesting that the mechanism of resistance may be applicable to other RNA viruses.

Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay

Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.

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  • Journal article
    Elderfield R, Barclay W, 2011,

    , HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN VIII, Vol: 719, Pages: 81-103, ISSN: 0065-2598
    • Cite
    • Citations: 20
  • Journal article
    Moncorge O, Mura M, Barclay WS, 2010,

    , JOURNAL OF VIROLOGY, Vol: 84, Pages: 9978-9986, ISSN: 0022-538X
    • Cite
    • Citations: 82
  • Journal article
    Hartgroves LCS, Koudstaal W, McLeod C, Moncorge O, Thompson CI, Ellis J, Bull C, Havenga MJE, Goudsmit J, Barclay WSet al., 2010,

    , VACCINE, Vol: 28, Pages: 2973-2979, ISSN: 0264-410X
  • Journal article
    Rehwinkel J, Tan CP, Goubau D, Schulz O, Pichlmair A, Bier K, Robb N, Vreede F, Barclay W, Fodor E, Reis e Sousa Cet al., 2010,

    , Cell, Vol: 140, Pages: 397-408

    RIG-I is a key mediator of antiviral immunity, able to couple detection of infection by RNA viruses to the induction of interferons. Natural RIG-I stimulatory RNAs have variously been proposed to correspond to virus genomes, virus replication intermediates, viral transcripts, or self-RNA cleaved by RNase L. However, the relative contribution of each of these RNA species to RIG-I activation and interferon induction in virus-infected cells is not known. Here, we use three approaches to identify physiological RIG-I agonists in cells infected with influenza A virus or Sendai virus. We show that RIG-I agonists are exclusively generated by the process of virus replication and correspond to full-length virus genomes. Therefore, nongenomic viral transcripts, short replication intermediates, and cleaved self-RNA do not contribute substantially to interferon induction in cells infected with these negative strand RNA viruses. Rather, single-stranded RNA viral genomes bearing 5'-triphosphates constitute the natural RIG-I agonists that trigger cell-intrinsic innate immune responses during infection.
  • Journal article
    Ayora-Talavera G, Shelton H, Scull MA, Ren J, Jones IM, Pickles RJ, Barclay WSet al., 2009,

    , PLOS ONE, Vol: 4, ISSN: 1932-6203
    • Cite
    • Citations: 57
  • Journal article
    Tsang J, Chain BM, Miller RF, Webb BLJ, Barclay W, Towers GJ, Katz DR, Noursadeghi Met al., 2009,

    , AIDS, Vol: 23, Pages: 2255-2263, ISSN: 0269-9370
    • Cite
    • Citations: 72
  • Journal article
    Johnson BF, Wilson LE, Ellis J, Elliot AJ, Barclay WS, Pebody RG, McMenamin J, Fleming DM, Zambon MCet al., 2009,

    , PLOS ONE, Vol: 4, ISSN: 1932-6203
    • Cite
    • Citations: 20
  • Journal article
    Wise HM, Foeglein A, Sun J, Dalton RM, Patel S, Howard W, Anderson EC, Barclay WS, Digard Pet al., 2009,

    , JOURNAL OF VIROLOGY, Vol: 83, Pages: 8021-8031, ISSN: 0022-538X
    • Cite
    • Citations: 300
  • Journal article
    Scull MA, Gillim-Ross L, Santos C, Roberts KL, Bordonali E, Subbarao K, Barclay WS, Pickles RJet al., 2009,

    , PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366
    • Cite
    • Citations: 62
  • Journal article
    Koudstaal W, Hartgroves L, Havenga M, Legastelois I, Ophorst C, Sieuwerts M, Zuijdgeest D, Vogels R, Custers J, de Boer-Luijtze E, de Leeuw O, Cornelissen L, Goudsmit J, Barclay Wet al., 2009,

    , VACCINE, Vol: 27, Pages: 2588-2593, ISSN: 0264-410X
    • Cite
    • Citations: 24

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Contact us

For any enquiries related to this group, please contact:

Professor Wendy Barclay
Chair in Influenza Virology 
+44 (020) 7594 5035
w.barclay@imperial.ac.uk